Physics at the Biomolecular Interface

Chapter 1 Interfacial Physics for Water in Biology.- Chapter 2 Dielectric Structure of Aqueous Interfaces: From Classical non-Debye Electrostatics to a Quantum Theory of Interfacial Tension.- Chapter 3 Solution to the Protein Folding Problem.- Chapter 4 Epistructural Dynamics of Biological Water.- Chapter 5 Dehydron-Rich Proteins in the Order-Disorder Twilight Zone.- Chapter 6 Dehydron as a Marker for Molecular Evolution: Lessons for the Drug Designer.- Chapter 7 Catalytic Role of Dehydrons in Soluble Proteins: Biological Chemistry of Frustrated Interfacial Water.- Chapter 8 Epistructural Selectivity Filters for Molecular Targeted Therapy.- Chapter 9 Epistructural Re-Engineering ofImatinib to Eliminate Adverse Side Effects.- Chapter 10 Epistructural Informatics for the Drug Designer.- Chapter 11 Drug-Target Associations Inducing Protein Folding.- Chapter 12 Combination Therapies to Edit Out Side Effects and Resistance to Inhibition of Drug Resistance.- Chapter 13 Epistructure-Based Design of Drugs with Controlled Promiscuity.- Chapter 14 Synergizing Engineered Immunotherapy with Molecularly Targeted Cancer Treatment.- Chapter 15 Quantum Mechanical Concepts for Epistructural Drug Design.- Chapter 16 Structure-Based Drug Discovery Without Structure: Working Around the Paradox to Disrupt Protein-Protein Associations.- Chapter 17 Epistructural Drug Design to Treat Cancer Metastasis and the Associated Drug Resistance.

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• Pesquisa médica
• Bioquímica
• Biofísica
• Química física
• Proteinas
• Cibernética e teoria dos sistemas

Interfacial biological water;Nanoscale water dielectrics;Protein-water interface;Solution to the protein folding problem;Protein structural defects;Interfacial tension in biology;Rational drug design;Dehydron-wrapping technologies;Drug specificity filters;Epistructural biology;Protein Structure