Integrins in Health and Disease

Part 1: Knockouts and animal models.- Integrins ?1?1 and ?2?1 - The generalist collagen receptors.- Roles for Integrin ?3?1 in Development and Disease.- Part 2: Fibrosis& Cancer.- Integrins: Key targets in tissue fibrosis and tumor stroma.- Integrins in Cardiac Form, Function and Disease.- Integrin ?8 and its ligand nephronectin in health and disease.- ?v integrin-dependent TGF? activation in cancer: a brief update.- Part 3: Human disease.- a11b1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis.- Integrins in pathological tissue remodelling of joints.- ?4 integrins in immune homeostasis and disease.- ?2-integrins in immunity: new roles for old players.- Structure and function of the leukocyte integrin ?M?2.- Part 4: Integrins in hemostasis, and immune control.- Platelet integrins: Critical mediators of haemostasis and pathological thrombus formation.- Integrins as receptors for bacterial and viral pathogens.

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• Proteinas
• Biologia Celular (citologia)

Integrins;Cell adhesion;Cell migration;Cell-extracellular matrix-signaling;Immunity;Intracellular invasion of pathogens;Extracellular matrix;Tumor fibrosis;Intracellular invasion of pathogens;Cell surface receptors;Cell-cell receptors