Cyclic Peptide Design

Cyclic Peptide Design

Goetz, Gilles

Humana Press Inc.

08/2020

332

Mole

Inglês

9781493995066

15 a 20 dias

655

Descrição não disponível.
Design Principles for Intestinal Permeability of Cyclic Peptides.- Strategies to Enhance Metabolic Stabilities.- Designing Cell-Permeable Macrocyclic Peptides.- Computational Methods for Studying Conformational Behaviors of Cyclic Peptides.- Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein-Protein Interactions.- Design of Cyclic Peptides as Protein Recognition Motifs.- Design and Synthetic Strategies for Helical Peptides.- Click Chemistry for Cyclic Peptides Drug Design.- Frontier between Cyclic Peptides and Macrocycles.- Building upon Nature's Framework: Overview of Key Strategies towards Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles.- Design of Oxytocin Analogs.- DNA-Encoded Macrocyclic Peptide Library.- Peptide Display Technologies.- Discovery of Functional Macrocyclic Peptides by Means of the RaPID System.- Genetic Selections with SICLOPPS Libraries: Towards the Identification of Novel Protein-Protein Interaction Inhibitors and Chemical Tools.
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Drug design;Small molecules;Natural product chemistry;Helical peptides;Cell permeability;Protein-protein recognition