Advances in Pharmacokinetics and Pharmacodynamics

Pharmacokinetics1. Current status in PBPK modeling.



Ryuta Asaumi, Kiyohiko Sugano, Ritsumeikan University, Japan suganok@fc.ritsumei.ac.jp



2. Physiologically based biopharmaceutics modeling (PBBM) Application on Food Effect Assessment.



Di Wu, John P. Gleeson, Filippos Kesisoglou, Biopharmaceutics Group, Merck, New Jersey, USA filippos_kesisoglou@merck.com



3. Physiologically based finite time pharmacokinetic (PBFTPK) models: Inception and development



Athanasios A. Tsekouras and Panos Macheras, National and Kapodistrian University of Athens, Greece macheras@pharm.uoa.gr



4. Physiologically based finite time pharmacokinetic (PBFTPK) models: Applications



Athanasios A. Tsekouras, Nikos Alimpertis, and Panos Macheras, National and Kapodistrian University of Athens, Greece macheras@pharm.uoa.gr



Pharmacodynamics



5. Pharmacokinetic - Pharmacodynamic Modelling and Simulation in Clinical Practice and Studies



Thomas P.C. Dorlo & Elin M. Svensson tdorlo@page-meeting.org



6. On the Verge of Impossibility: Accounting for Variability Arising from Permutations of Comorbidities that Affect the Fate of Drugs in the Human Body.



Amin Rostami-Hodjegan, University of Manchester, Vice President of Research & Development at Simcyp Ltd (a Certara Company) amin.rostami@manchester.ac.uk and Brahim Achour brahim.achour@manchester.ac.uk



7. Impact of Clinical Pharmacology on the Modernization of Drug Development and RegulationCarl Peck ccpeck@icloud.com and Liang Zhao liang.zhao@fda.hhs.gov

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• Química
• Medicina pré-clínica: ciências básicas
• Farmacologia
• Biotecnologia
• Bioquímica
• Metabolismo

drug delivery;pharmacokinetics;pharmacodynamics;PBPK models;biopharmaceutics;pbftpk models;pk/pd modles;reproducibility;subject variability;physiology variability