Implication of Oxysterols and Phytosterols in Aging and Human Diseases

Part I. Chemical Characteristics.- Chapter 1. The Structure of Oxysterols Determines their Behavior at Phase Boundaries - Implications for Model Membranes and Structure-Activity Relationships.- Chapter 2. Association of ABCG5 and ABCG8 Transporters with Sitosterolemia.- Part II. Bio- and Chemical- Synthesis, and Analytical Methods.- Chapter 3. Chemical and Biochemical Features of Spinasterol and Schottenol.- Chapter 4. LC-MS Approaches for Oxysterols in Various Biosamples.- Chapter 5. Mass Spectrometry Imaging of Cholesterol and Oxysterols.- Part III. Implication in Aging and Human Diseases.- Chapter 6. Oxysterols in Central and Peripheral Synaptic Communication.- Chapter 7. Oxysterols in Infectious Diseases.- Chapter 8. The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases.- Chapter 9. Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects.- Chapter 10. Enzymatically Formed Oxysterols and Cell Death.- Chapter 11. Oxysterols in Vascular Cells and Role in Atherosclerosis.- Chapter 12. Implication of Oxysterols and Phytosterols in Aging and Human Diseases.- Chapter 13. Sterols in Inflammatory Diseases: Implications and Clinical Utility.- Chapter 14. Role of Oxysterols in Ocular Degeneration Mechanisms and Involvement of P2X7 Receptor.- Chapter 15. 24S-Hydroxycholesterol in Neuropsychiatric Diseases: Schizophrenia, Autism Spectrum Disorder and Bipolar Disorder.- Part IV. Biomarkers Therapeutic and Industrial Applications.- Chapter 16. Oxysterols as Biomarkers of Aging and Disease.- Chapter 17. The Diagnostic Use of the Plasma Quantification of 24S-Hydroxycholesterol and Other Oxysterols in Neurodegenerative Disease.- Chapter 18. Oxy- and Phytosterols as Biomarkers: Current Status and Future Perspectives.- Part V. Pharmacological Applications.- Chapter 19. Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancer.- Part VI. Industrial Aspects.- Chapter 20. Current and New Insights on Delivery Systems for Plant Sterols in Food.- Chapter 21. In vitro Evaluation of the Effects of 7-Ketocholesterol and 7?-Hydroxycholesterol on the Peroxisomal Status: Prevention of Peroxisomal Damages and Concept of Pexotherapy.- Chapter 22. Phytosterols: Potential Therapeutic Effects and Challenges in Food Industry.

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• Imunologia
• Química orgânica
• Biologia Celular (citologia)
• Biologia, ciências da vida
• Química
• Medicina pré-clínica: ciências básicas
• Oncologia

Aging;Atheroslecrosis;Autoimmune Disease;Biomarker;Cancer;Cholesterol;Chemical Characteristics;7-Ketocholesterol;Lipid Oxidation;Lipid Synthesis;LXR;Mass Spectrometry;Neurodegenerative Diseases;Oxysterol;Peroxisome;Respiratory Infection;Skin Disorders