iPSCs - State of the Science

1. Revealing Nervous and Cardiac System Interactions by iPSC-Based Platforms 2. Human iPSC Models of Cardiac Electrophysiology and Arrhythmia 3. Human iPSCs for Modeling of Hepatobiliary Development and Drug Discovery 4. The application of iPSC-derived kidney organoids and genome editing in kidney disease modeling 5. Towards the in vitro understanding of iPSC nucleoskeletal and cytoskeletal biology, and their relevance for organoid development 6. Induced Pluripotent Stem Cell Models for Mitochondrial Disorders 7. Induced Pluripotent Stem cells for Studying Genetic Autonomic Disorders 8. Applications of iPSCs in Gaucher Disease and other rare sphingolipidoses 9. Application of CRISPR/Cas system in iPSC-based disease model of hereditary deafness 10. Progress and Possibilities for Patient-Derived iPSCs and Genetically Engineered Stem Cells in Cancer Modeling and Targeted Therapies

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• Biologia Celular (citologia)
• Ciências da vida: temas gerais

Abnormal automaticity; Actin; Action potential; Aging; Arrhythmia; Autonomic nervous system; Biobank; Bioenergetics; Cancer etiology; Cardiac differentiation; Cardiac innervations; Cardiology; Cardiomyocyte; Cardiomyopathy; Cardiovascular disease; Cell biology; Cell therapies; Cell therapy; Cellular therapy; Channelopathy; Cholangiocyte differentiation; Cholangiocyte; Cholangiocytes; CRISPR/Cas9Deafness; CRISPR/Cas9Directed differentiation; Cytoskeleton; Definitive endoderm; Delayed afterdepolarization; Diagnostic platform; Differentiation; Disease model; Disease modeling; Disease progression; Drug discovery; DSB; Early afterdepolarization; Electron transport chain; Electrophysiology; Embryonic stem cells; Enteric neurons; Familial dysautonomia; Gaucher disease; GD-specific iPSCs; Gene editing; Gene therapy; Genetic autonomic disorders; Genetic diseases; Genetic disorders; Genome editing; HDR; Hearing loss; Hepatocyte differentiation; Hepatocyte-like cells; Hepatocytes; Hepatotoxicity; Hirschsprung's disease; Human embryonic stem cell; Human pluripotent stem cells; Hypoxia; Idiosyncratic drug reaction; Immunotherapy; In vitro disease models; Induced pluripotent stem cell; Induced pluripotent stem cells; Inner ear hair cell; Intermediate filaments; iPSC; Kidney development; Kidney disease modeling; Kidney organoid; Kidney; Lamin A/C; Lamin; Liver development; Liver disease; Lysosomal storage disorders; Lysosome; Metabolic disorders; Microfluidics; Microtubules; Miniorgans; Mitochondria; Mitochondrial disease; mtDNA; Multiple system atrophy; Multisystemic diseases; Mutation and deletion; Nervous system; Neural crest; Neural differentiation; Neurodegenerative diseases; Neuronal differentiation; NHEJ; Nucleoskeleton; Organoid; Organoids; Organ-on-a-chip; Otic progenitors; Oxidative stress; p53Reprogramming; Parasympathetic neurons; Peripheral nervous system; Personalized medicine; Pluripotent stem cells; Pure autonomic failure; Reentry; Regenerative medicine; Reprogramming; Respiratory chain diseases; Sensorineural; Sensory neurons; Sphingolipidoses; Spiral wave; Stem cell biology; Stem cell; Stiffness; Sympathetic neurons; Targeted therapies; Tissue engineering; Transcription; Transmembrane voltage; Triggered activity; Tumorigenesis