Vaccine Efficacy Evaluation

Vaccine Efficacy Evaluation

The Gnotobiotic Pig Model

Yuan, Lijuan

Taylor & Francis Ltd

04/2022

189

Dura

Inglês

9781032234748

15 a 20 dias

539

Descrição não disponível.
Preface. Acknowledgments. About the Author. Introduction. Establishment of Gn Pig Model of HRV Infection and Diarrhea: Infectivity and Pathogenesis of HRV in Gn Pigs. Establishment of Gn Pig Model of HuNoV Infection and Diarrhea. Evaluation of Live Oral and Inactivated Intramuscular HRV Vaccines in Gn Pigs. Virus-like Particles Given Intranasally or DNA Plasmids Given Intramuscularly Failed to Induce Any Protection in Gn Pigs. Prime-Boost Rotavirus Vaccine Regimens Are Highly Effective. Rotavirus P2-VP8* and P24-VP8* Intramuscular Vaccines Evaluated in Gn Pigs. Norovirus P Particle and VLP Vaccines Evaluated in Gn Pig Model of GII.4 HuNoV Infection and Diarrhea. Simvastatin Reduces Protection and Intestinal T cell Responses Induced by a Norovirus P Particle Vaccine in Gnotobiotic Pigs. Dissecting Importance of B Cells versus T Cells in Rotavirus Vaccine-Induced Immunity Using Gene Knockout Gn Pigs. Human Gut Microbiota-Transplanted Gn Pig Models for HRV Infection. Probiotics Modulate Adaptive Immune Responses to Oral HRV Vaccines in HGM Transplanted Gn Pigs. Probiotics Modulate Cell Signaling Pathway and Innate Cytokine Responses to Oral HRV Vaccine in HGM-Transplanted Gn Pigs. Probiotics as HRV Vaccine Adjuvants in Gn Pigs. Rice Bran as a Vaccine Adjuvant and as Prebiotics in Reducing Viral Diarrhea. References. Index.
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Germ-free models;Human Rotaviruses;Probiotics;Virus-like Particles;Rotavirus Specific IgA;IgG Memory;IgG Antibody Titer;DNA Vaccine;Kruskal Wallis Rank Sum Test;IgG Antibody Response;IgG Titer;Rotavirus Infection;Rotavirus Vaccines;HRV Vaccine;Treg Cells;VN Antibody;Fecal Consistency Score;DNA Plasmid;MHC Ii;Rotavirus Antigen;Diarrhea Scores;IgG Antibody;VLP Vaccine;Gut Microbiota;Viral RNA Copy;IgA Titer;Virus Shedding;Intestinal IgA