Activation and Detoxification Enzymes

Overview.- Foreign Compounds: Foods, Drugs, Chemicals and Life Styles.- Transport and Excretion of Foreign Compounds.- Metabolic Conversion of Foreign Compounds.- Phase I Activation Enzymes.- Phase II Detoxification Enzymes.- Catalytic Reactions of Activation Enzymes.- Catalytic Reactions of Detoxification Enzymes.- Reactive Intermediates and their Interactions.- Metabolite - Associated Cell Toxicities.- Oxidative Stress and Electrophilic Stress.- Metabolic Enzymes: Polymorphism and Species Differences.- Defense Against Oxidative Stress: Nrf2-ARE Pathway.- Inducibility of Metabolic Enzymes.- Inducers of Metabolic Enzymes.- Diversified Classes of Enzyme Modulators.- Metabolite - Mediated Disease Conditions.- Metabolic Enzyme Induction for Health Benefits.- Diet Effects on Metabolic Enzymes.

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• Fisiologia
• Farmacologia
• Biologia, ciências da vida
• Química orgânica
• Dietética e Nutrição
• Modelagem computacional e simulação

toxins;xenobiotics;lipophilic compounds;detoxification;metabolomics;foreign compounds;NFR2;enzymes;activation enzymes;detoxification enzymes