Understanding the Pandemic

Section 1: Coronaviruses (including SARS 1 and MERS), the Structure (sequence), Mechanism of Action Introduction 1. Origin, Evolution and Spread of SARS-CoV-2 2. SARS-CoV-2 Spike Proteins in Infectivity 3. Structural and functional properties of the SARS-CoV-2 spike protein: potential vaccine and drug development for COVID-19 4. Population-Specific Polymorphisms and SARS-CoV-2 Infectivity 5. Insights into SARS-CoV-2 Structure: Approaches and Action of SARS-CoV-2 Main Protease Inhibitors 6. SARS-CoV-2, SARS-CoV, and MERS-COV: Similarities and Differences in Origin and Transmission Section 2: Inflammation and Immune Response to SARS-CoV-2 Introduction 7. Characterization of the Immune Response with Viral Attack 8. Inflammation, Cytokines and COVID-19 Severity 9. Immunological Considerations for COVID-19: Vaccines and Other Protective Strategies 10. Virus-specific T cell response in SARS-CoV-2 infection and vaccinations 11. Oral and Gut Inflammation and Microbiota with COVID-19 12. Implications of Inflammation: Bone and Joint Health with COVID-19 13. COVID-19 and immune dysfunction: Consequences, and natural remedies for management Section 3: Pathological Findings with Clinical Correlation Introduction 14. Pulmonary Pathology of Severe Covid-19 15. Histopathological Analysis of the Cardiovascular System in severe COVID-19 16. Postmortem Neuropathology in COVID-19 17. Renal Pathology in Severe Covid-19 Section 4: The Blood Vessels and COVID-19: Vascular Dysfunction and Coagulopathies Introduction 18. Vascular Manifestations of COVID-19: Endothelial Dysfunction and Damage 19. Immunothrombosis involvement in COVID-19 20. COVID-19 associated coagulopathy 21. D-dimer in systemic circulation and COVID-19 outcome 22. Hypercoagulability in COVID-19 Section 5: Neuro-COVID-19 and its Long-Term Implications Introduction 23. COVID and the Nervous System: Mechanisms and Consequences 24. Neuroinflammation: Unraveling Acute and Long COVID-19 Effects 25. Acute and Post-acute Neurologic and Psychiatric Manifestations in COVID-19 26. Pediatric Neurological and Neuropsychiatric Manifestations of COVID-19 27. Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of Covid-19 Section 6: Should Covid-19 Concern Nephrologists? Why and to What Extent?" Introduction 28. Acute Kidney Injury with COvid-19: Mechanisms, Management, and Long-term Outcomes 29. Models and Cellular Monolayers to Study the Effect of SARS-CoV-2 on Kidneys 30. Clinical implications of COVID-19 in chronic kidney disease and end-stage kidney disease Section 7: Long COVID-19 (long term effects - summarizing of clinical reports in literature) Introduction 31. Long COVID or Post-Acute Sequalae of COVID: An introduction 32. Long COVID: Pathophysiology and classification 33. Gender differences in Sequelae from COVID-19 Infection 34. Characterizing Long COVID-19: Lessons in the Clinic. 35. Implications of Long COVID for the Global Health Care System Section 8: The Vaccines Introduction 36. COVID-19: The Vaccine Development Strategies 37. mRNA vaccines: The New Frontier 38. Covid-19 vaccines: A Comprehensive review of Safety and Efficacy Section 9: Handling the Spread: Public Health and Social Measures Introduction 39. Lockdown measures during the COVID-19 pandemic 40. Efficacy of Facial masks against COVID-19 41. Vaccination Policies 42. Navigating the Impact of COVID-19 School Closures on Child Health, Education, and Society: A Call to Embrace Civil Discourse Across Identities, Sectors, and Disciplines 43. The Effect of the Pandemic on Care for Other Health Conditions 44. The role of smartphone-assisted tools for Covid-19 diagnostic, treatment, and quarantine Section 10: From the Editors' desk 45. What have we learnt from the COVID-19 pandemic?

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• Doenças infecciosas e contagiosas
• Epidemiologia e estatística médica

COVID-19; SARS-CoV-2; coronavirus; virus; pandemic; transmission; pathophysiology; inflammation; immune response; comorbidities; organ damage; long COVID-19; vaccine