Targeting Enzymes for Pharmaceutical Development

Measuring Protein-Ligand Binding by Thermal Shift Assay.- Applications of Differential Scanning Fluorimetry and Related Technologies in Characterization of Protein-Ligand Interactions.- Enzyme-Ligand Interaction Monitored by Synchrotron Radiation Circular Dichroism.- Binding Interaction Analysis of Lysozyme and Brilliant Blue using Surface Plasmon Resonance.- Evaluation of Endolysin Activity Using Nephelometric Assays with Whole Bacterial Cells and Isolated Peptidoglycan.- In Vitro Assays for Endolysin Efficacy and Safety Profiling.- Droplet-Based Microfluidics Methods for Detecting Enzyme Inhibitors.- HMG-CoA Reductase Inhibition Assays: Updated Protocols for Drug Discovery and Enzyme Kinetics.- The Enzyme-Bag Platform for Cytochrome P450 Biotransformation and High-Throughput Drug Metabolism Screening.- Enzymatic Bioautographic Methods.- On-Line Enantioselective Capillary Electrophoretic Method for Screening Cytochrome P450 3A4 Inhibitors.- Isolation and Endopeptidase Inhibition of Human ?2-Macroglobulin.- Harnessing Affinity Tags for Recombinant Protein Purification: Concepts, Methods, and Troubleshooting.- Computational Strategies for Discovering Inhibitors Targeting Therapeutic Enzymes.- Computational Study of Enzyme Inhibition.- In Silico Laboratory: New and Updated Tools for Protein-Centered Drug Discovery.- Combined In Silico Approaches for Virtual Screening of Non-Covalent Immunoproteasome Inhibitors for Multiple Myeloma Treatment.- Deep Learning Pipeline for Accelerating Virtual Screening in Drug Discovery.- In Silico Methodology for Human Carboxylesterases 1 and 2 Isoforms Substrate Selectivity Study.

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• Química orgânica
• Biologia, ciências da vida
• Farmacologia

Drug discovery;Enzyme inhibitors;Therapeutic targets;Enzymatic assays;Biotechnology