Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues

Introduction.- In the Beginning.- The Enigma of Edith: Free Energy, Nucleation and the Formation of Mineral.- Form and Function of Tissues that Undergo Mineralization.- Genes and Gene Networks Regulating Mineralization.- Calcium and Phosphate Ion Uptake, Distribution and Homeostasis in Cells of Vertebrate Mineralizing Tissues.- Calcium and Phosphate Ion Efflux from Cells: The Roles of Matrix Vesicles, Extracellular Vesicles, and Other Membrane-invested Transporters in Vertebrate Hard Tissue Mineralization.- Collagen-based Mineralization of Bones, Teeth and Other Vertebrate Skeletal Tissues.- The Role of Non-collagenous Proteins and Other Matrix Molecules in Vertebrate Mineralization.- Local and Systemic Regulation of Mineralization: Role of Coupling Factors, Pyrophosphate, Polyphosphates, Vitamin D, Fetuin, Matrix Gla Protein and Osteopontin.- Observations Concerning Mineral Deposition in Soft Tissues: Regulation of Aberrant Mineral Deposits.- Epilogue.

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• Química
• Ortopedia e fracturas
• Biologia Celular (citologia)
• Medicina interna e clínica
• Medicina pré-clínica: ciências básicas
• Ciências da vida: temas gerais
• Odontologia

apatite, enamel;bone;calcification;cartilage;dentine;mineralization