Genetic and Epigenetic Damage in Human Spermatozoa

Evaluating sperm DNA damage when and why it adds to the management of the infertile man.- Evaluating sperm DNA damage when and why it does not add to the evaluation of male factor infertility.- Comparing methods for sperm DNA fragmentation detection.- Sperm selection procedures in cases of high sperm DNA fragmentation index.-Environmental lifestyle and other factors affecting sperm DNA integrity.- Effects of cytotoxic therapies on the sperm genome and epigenome.- Gene defects and sperm abnormalities.- Genetic evaluation of the infertile man indications to whole exome sequencing.- Epigenetic developmental plasticity effect on fertility and on offsprings health.- The sperm epigenome implications for medically assisted reproduction.- Methods for investigating the sperm epigenome.- Sperm non coding RNAS how to test when and to whom.

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• Genética médica
• Biologia molecular
• Genética (não médica)
• Medicina reproductiva

epigenetic damage;genetic damage;human spermatozoa;sperm DNA;sperm non-coding RNAs;sperm genome;sperm epigenome;gene defects;infertility;DNA fragmentation;reproductive health