Drug Discovery with Privileged Building Blocks
portes grátis
Drug Discovery with Privileged Building Blocks
Tactics in Medicinal Chemistry
Yang, Minmin; Li, Jie Jack
Taylor & Francis Ltd
10/2021
306
Dura
Inglês
9781032041735
15 a 20 dias
848
Descrição não disponível.
Preface 1. Alkynes; 2. Azaindoles; 3. Azetidines; 4. Bicyclic Pyridines Containing Ring-junction N; 5. Bicyclo (1.1.1)pentyl (BCP) as an sp3 Carbon-rich Bioisostere for para-Phenyl and tert-Butyl Groups; 6. Bicyclo[2.2.2]octane (BCO) as A 3D-rich Bioisotere for the para-Phenyl Group; 7. Bicyclo[3.1.0]hexanes; 8. Bridge-Fused Rings as m-Phenyl Bioisosteres; 9. Cubanes, Are We There Yet?; 10. Cyclobutanes; 11. Cyclohexanes; 12. Cyclopentanes; 13. Cyclopropanes as Metabolically More Robust Bioisoteres for Linear Alkyl Substituents; 14. Deazapurines; 15. Furopyridines; 16. Indazoles; 17. Indoles; 18. Oxetanes; 19. Piperidine, the Enchanted Ring; 20. Pyrazines; 21. Pyrazoles; 22. Pyridazines; 23. Pyridines - The Magic of Phenyl-Pyridyl Switch; 24. Pyrimidines; 25. Pyrrolidines; 26. Pyrrolotriazines; 27. Spiroazetidines; 28. Spirocyclic Piperidines; 29. Spirocyclic pyrrolidines; 30. Spirooxetanes; 31. Tetrahydropyrans; 32. Trifluoromethylpyridines. Index
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SBDD;Hydrogen Bond Acceptors;FAAH;HTS;Ar Displacement;Boc Protective Group;ADME Profile;ADME;SFC;NS5B;Treating Castration Resistant Prostate Cancer;Privileged Scaffold;PI3K? Selective Inhibitor;Apalutamide;HCV Infection;NS5A;LLE;IRAK4 Inhibitor;Suzuki Coupling;Metabotropic Glutamate Receptor;Buchwald Hartwig Coupling;BACE1;Dess Martin Oxidation;Drug's Aqueous Solubility;HCV NS5B
Preface 1. Alkynes; 2. Azaindoles; 3. Azetidines; 4. Bicyclic Pyridines Containing Ring-junction N; 5. Bicyclo (1.1.1)pentyl (BCP) as an sp3 Carbon-rich Bioisostere for para-Phenyl and tert-Butyl Groups; 6. Bicyclo[2.2.2]octane (BCO) as A 3D-rich Bioisotere for the para-Phenyl Group; 7. Bicyclo[3.1.0]hexanes; 8. Bridge-Fused Rings as m-Phenyl Bioisosteres; 9. Cubanes, Are We There Yet?; 10. Cyclobutanes; 11. Cyclohexanes; 12. Cyclopentanes; 13. Cyclopropanes as Metabolically More Robust Bioisoteres for Linear Alkyl Substituents; 14. Deazapurines; 15. Furopyridines; 16. Indazoles; 17. Indoles; 18. Oxetanes; 19. Piperidine, the Enchanted Ring; 20. Pyrazines; 21. Pyrazoles; 22. Pyridazines; 23. Pyridines - The Magic of Phenyl-Pyridyl Switch; 24. Pyrimidines; 25. Pyrrolidines; 26. Pyrrolotriazines; 27. Spiroazetidines; 28. Spirocyclic Piperidines; 29. Spirocyclic pyrrolidines; 30. Spirooxetanes; 31. Tetrahydropyrans; 32. Trifluoromethylpyridines. Index
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
SBDD;Hydrogen Bond Acceptors;FAAH;HTS;Ar Displacement;Boc Protective Group;ADME Profile;ADME;SFC;NS5B;Treating Castration Resistant Prostate Cancer;Privileged Scaffold;PI3K? Selective Inhibitor;Apalutamide;HCV Infection;NS5A;LLE;IRAK4 Inhibitor;Suzuki Coupling;Metabotropic Glutamate Receptor;Buchwald Hartwig Coupling;BACE1;Dess Martin Oxidation;Drug's Aqueous Solubility;HCV NS5B
