Tumor Suppressor Par-4

Tumor Suppressor Par-4

Structural Features, Molecular Mechanisms and Function

Rangnekar, Vivek M.

Springer Nature Switzerland AG

01/2022

323

Dura

Inglês

9783030735715

15 a 20 dias

670

Descrição não disponível.
Discovery and Overview of Par-4.- Par-4 in cell cycle regulation.- Conformational studies of the Par-4 C-terminal Domain.- Structural analysis of Par-4 and crystallographic analysis of the regulatory domain.- Regulation of Par-4 by Ubiquitinases.- REGULATION OF PAR-4 FUNCTION BY PHOSPHORYLATION.- Role of Par-4 in GRP78 translocation.- PAR-4 in the regulation of stem cell death and embryo development.- RASSF2 and the PAR-4 connection.- Regulation of tumor suppressor Par-4 by ceramide.- PAWR as a direct SRC-1/HOXC11 suppression target.- Index.
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prostate;par-4;apoptosis;cancer cells;protein;clinical trial;translational research;stem cells;PKA;THAP1;cell surface receptor GRP78;zebrafish;FDA-approved drugs;DAPK;AMIDA