Thymus Transcriptome and Cell Biology

Thymus Transcriptome and Cell Biology

Passos, Geraldo A.

Springer Nature Switzerland AG

08/2020

318

Mole

Inglês

9783030120429

15 a 20 dias

516

Descrição não disponível.
1. History of the thymus: From a vestigial organ to the programming of immunological self-tolerance.- 2. Thymus Ontogeny and Development.- 3. The Ins and Outs of Thymic Epithelial Cell Differentiation and Function.- 4. T-Cell Development: From T-Lineage Specification to Intrathymic Maturation.- 5. Intrathymic cell migration: implications in thymocyte development and T-cell repertoire formation.- 6. Thymic crosstalk: an overview of the complex cellular interactions that control the establishment of T-cell tolerance.- 7. The Autoimmune Regulator (AIRE) gene, the master activator of self-antigen expression in the thymus.- 8. Aire Mutations and Autoimmune Diseases.- 9. The thymus as a mirror of the body's gene expression.- 10. Functional genomics of the infant human thymus: Aire and minipuberty.- 11. Thymus transcriptome of TGF-? superfamily.- 12. Development of thymic regulatory T lymphocytes.- 13. Adding insult to injury: improving the regenerative capacity of the aged thymus following clinically induced damage.- 14. Thymus rejuvenation after autologous hematopoietic stem cell transplantation in patients with autoimmune diseases.
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Transcriptomics;central immune tolerance,;thymus gland;autoimmunity;Aire gene;Crispr-Cas9.;Systems Biology