TDP-43 and Neurodegeneration

TDP-43 and Neurodegeneration

From Bench to Bedside

Kumar, Vijay; Jaiswal, Manoj Kumar

Elsevier Science Publishing Co Inc

10/2021

270

Mole

Inglês

9780128200667

15 a 20 dias

410

Descrição não disponível.
1. TDP-43: Past, Present and Future
2. Structural studies of TDP-43
3. TDP-43 mutations and Amyotrophic Lateral Sclerosis
4. Post translational modifications of TDP-43
5. TDP-43 and Autophagy
6. TDP-43 and Alzheimer Disease
7. TDP-43 and Stress granules
8. Repeat domains in TDP-43
8. Systems Biology of TDP-43
9. Animal models of TDP-43 in ALS
10. Therapeutic modulations of TDP-43
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Acetylation; Aggregates; Aggregation; ALS; Alzheimer's disease (AD)Amyotrophic lateral sclerosis (ALS)Cytoplasmic aggregates; Alzheimer's disease (AD)Amyotrophic lateral sclerosis (ALS)Frontotemporal dementia (FTD)Lewy body dementia (LBD)Parkinson disease (PD)TARDBP; Amyloid; Amyotrophic lateral sclerosis (ALS)C-terminal fragmentation; Amyotrophic lateral sclerosis; Autophagy; C-terminal domain; Cysteine oxidation; Disordered regions; EWS; Frontotemporal dementia (FTD)Frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP)Phosphorylation; Frontotemporal dementia (FTD)Pharmacological interventions and drug discovery; Frontotemporal lobar degeneration; FUS; Hsp104Neurodegeneration; Neurodegenerative diseases; Neurotherapeutics; Nonmammalian models; N-terminal domain; Oxidative stress; Prion; Protein interaction networks; Protein-protein interaction network; Randomized clinical trial (RCT)Repeats; RNA recognition Motifs; RNA-binding protein; Spatiotemporal expression; Structure; TAF15TDP-43TAR DNA-binding protein 43TDP-43Transactive response DNA-Binding protein 43 (TDP-43)Ubiquitination