Senolytics in Disease, Ageing and Longevity

Part I: Origins and Development of Senotherapies.- Chapter 1. Senolytic drug development.- Chapter 2. Discovery of Senolytics and the pathway to early phase clinical trials.- Part II: The Impact of Senotherapies: from Regeneration to Aging.- Chapter 3. Interconnection between cellular senescence, regeneration and ageing in salamanders.- Chapter 4. Senolytics target senescent cells and improve aging and age-related diseases.- Chapter 5. Senotherapy of cancer.- Part III: Understanding and Targeting the Senescent Surfaceome.- Chapter 6. Targeted senolytic strategies based on the senescent surfaceome.- Chapter 7. Senolysis and senostasis through the plasma membrane.- Part IV: Novel Senescence-Associated Markers and Targets.- Chapter 8. In situ detection of miRNAs in senescent cells in archival material.- Chapter 9. Novel probes and carriers to target senescent cells.- Chapter 10. Potential applications of aptamers for targeting senescent cells.- Chapter 11. Mitochondria: potential targets for interventions to counteract senescence.

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• Biotecnologia
• Medicina geriátrica
• Biologia, ciências da vida
• Equipamentos científicos, experiências e técnicas
• Pesquisa médica

Ageing;Regenerative Medicine;Cellular Senescence;Tissue Engineering;Senotherapies;Senoprobes;Preclinical and Early-Phase Trial Studies;biogerontology