Polycystic Kidney Disease

Polycystic Kidney Disease

Yu, Yong; Hu, Jinghua

Taylor & Francis Ltd

09/2021

360

Mole

Inglês

9781032176581

15 a 20 dias

598

Descrição não disponível.
1. Biochemical Analysis of the Polycystin-1 Complexity Generated by Proteolytic Cleavage at the G Protein-Coupled Receptor Proteolysis Site. 2. Structural Determination of the Polycystin-2 Channel by Electron Cryo-Microscopy. 3. Recording Ion Channels in Cilia Membranes. 4. Electrophysiological Recording of a Gain-of-Function Polycystin-2 Channel with a Two-Electrode Voltage Clamp. 5. Functional Studies of PKD2 and PKD2L1 through Opening the Hydrophobic Activation Gate. 6. Analyzing the GPCR Function of Polycystin-1. 7. Methods to Study the Vasculature in ADPKD. 8. Energy Metabolism, Metabolic Sensors, and Nutritional Interventions in Polycystic Kidney Disease. 9. "Kidney in a Dish" Organoids for PKD. 10. Rodent Autosomal Dominant Polycystic Kidney Disease Models. 11. Using C. elegans as a Model in PKD. 12. Approaches to Studying Polycystic Kidney Disease in Zebrafish. 13. Investigation of DNA Methylation in Autosomal Dominant Polycystic Kidney Disease. 14. Molecular Diagnosis of Autosomal Dominant Polycystic Kidney Disease.
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PKD1 Gene;Total Kidney Volume;nephrology;ADPKD;kidney physiology;DNA Methylation;ciliar struction and function;SIRT1 Activation;autosomal genetic diseases;ADPKD Patient;molecular mechanisms of disease;Primary Cilia;PKD1;NGM Plate;PC1 Protein;TRPP2;Trp Channel;abnormal cilia formation;Step-by Step Protocol;tubular epithelial cells;Extra-renal Manifestations;Gate Residue;HEK293T Cell;DNA Methylation Analysis;DNA Capture;Rock Inhibitor;Cell Free DNA;EV Sample;PCK Rat;Motile Cilia;Blocking Buffer;DNA Methylation Status;Bisulfite Conversion;Cilia Membrane