Non-heme Iron Enzymes: Structures and Mechanisms

1. Non-heme iron enzyme-catalyzed complex transformations: endoperoxidation, cyclopropanation, orthoester, oxidative C-C and C-S bond formation reactions in natural product biosynthesis - Heng Song, Nathchar Naowarojna, Ronghai Cheng, Lopez Juan, and Pinghua Liu 2. Glutarate L-2-hydroxylase (CsiD/GlaH) is an archetype Fe(II)/2-oxoglutarate-dependent dioxygenase - Caitlyn Q Herr, Lee Macomber, Efthalia Kalliri, and Robert P. Hausinger 3. Comparison of DNA and RNA substrate effects on TET2 structure - Emmett M. Leddin and G. Andres Cisneros 4. Structure-function relationships in KDM7 histone demethylases - Shobhit S. Chaturvedi, Rajeev Ramanan, Sodiq O. Waheed, Tatyana G. Karabencheva-Christova, and Christo Z. Christov

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• Bioquímica
• Biologia molecular
• Biologia Celular (citologia)
• DNA e Genoma

2-Oxoglutarate; Alpha-ketoglutarate; Ferrous ion; Histone lysine demethylases; Hydroxylase; KDM7Molecular dynamics; Non-heme iron; Oxygenase; QM/MM;