Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Contributions of extracellular (ECM) constituents to the mechanical function of soft biological tissue.- Structure-based constitutive modeling of ECM mechanics.- Advanced optical imaging of ECM structures in biological systems -fundamental research and clinical applications.- Discrete fiber network modeling of ECM networks.- Microstructural mechanisms and contributions of elastin and collagen to the elastic and viscoelastic behavior of soft biological tissues.- Scale-dependency of multi-scale ECM mechanics and measurements.- Bridging scales - multi-scale mechanics of engineered and native tissue.- Mechanical and biological interactions between cells and ECM.- Multi-physics modeling of ECM mechanics.

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• Física médica
• Engenharia biomédica
• Biofísica
• Mecânica dos sólidos

Biomechanics;Biomechanical characterization;Cell-matrix interactions;Collagen;Constitutive modeling;Discrete network model;Extracellular matrix;Elastin;Focal adhesion;Glycosaminoglycan;Mechanobiology;Mechanotransduction;Optical imaging