Methods for Studying Nucleic Acid/Drug Interactions

Methods for Studying Nucleic Acid/Drug Interactions

Tor, Yitzhak; Wanunu, Meni

Taylor & Francis Ltd

11/2018

392

Mole

Inglês

9781138382039

15 a 20 dias

750

Descrição não disponível.
CLASSICAL TECHNIQUES: Using Spectroscopic Techniques to Examine Drug-DNA Interactions. Probing DNA and RNA Interactions with Biogenic and Synthetic Polyamines: Models and Biological Implications. EMERGING TECHNIQUES: Mass Spectrometry-Based Techniques for Studying Nucleic Acid/Small Molecule Interactions.
Real-Time Monitoring of Nucleic Acid Interactions with Biosensor-Surface Plasmon Resonance. Studying Aptamer/Ligand Interactions Using Fluorescence Correlation Spectroscopy. Studying Nucleic Acid - Drug Interactions at the Single Molecule Level Using Optical Tweezers. Fluorescent Nucleoside Analogues for Monitoring RNA-Drug Interactions. Atomic Force Microscopy Investigation of DNA-Drug Interactions. Characterizing RNA-Ligand Interactions Using 2-Dimensional Combinatorial Screening. EPR Spectroscopy for the Study of RNA-Ligand Interactions. Electrochemical Approaches to the Study of DNA-Drug Interactions. Nanopore Ion Microscope for Detecting Nucleic Acid/Drug Interactions. A Primer for Relaxation Kinetic Measurements. DNA-Drug Interactions: A Theoretical Perspective. Computational Studies of RNA Dynamics and RNA-Ligand Interactions.

All chapters include case studies, background and basics, prospects and outlook, conclusions, and references
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Optical Tweezers;Calf Thymus DNA;drug binding assay;High Throughput Screening;fluorescence correlation spectroscopy;Groove Binding;nucleic acid/drug complexes;RNA Target;DNA/ligand interactions;Free DNA;RNA/ligand interactions;DNA Molecule;vibrational spectroscopy;Domain IIA;Contour Length;Hammerhead Ribozyme;Base Pairs;DNA Complex;EPR Spectroscopy;Minor Groove;Nucleic Acid;RNA Domain;Spin Label;Case Study;DNA Drug Interaction;Tat Protein;Intercalating Drugs;Fret Pair;Mass Transfer;Synthetic Polyamine;27mer RNA