Intrinsically Disordered Proteins

1. Introduction to intrinsically disordered proteins and regions

PART I - Methodology 2. Ensemble descriptions of IDPs and IDRs: Integrating simulation and experiment 3. Experimental characterization of the dynamics of IDPs and IDRs by NMR 4. Single-molecule fluorescence studies of IDPs and IDRs

PART II - Molecular Mechanism 5. Experimental studies of binding of intrinsically disordered proteins to their partners 6. Modeling protein-protein interactions with intrinsically disordered proteins

PART III - Biology and Medicine 7. IDPs and IDRs in biomolecular condensates 8. Molecular mechanisms of fibrillation of IDPs 9. Perspectives on drug discovery strategies based on IDPs 10. Conclusion and future directions

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• Proteinas
• Biofísica

IDPs; Intrinsically Disordered Proteins; Intrinsically Disordered Protein; IDP; Protein Regions; IDR; Intrinsically Disordered Regions; IDP complex; Protein Regions; IDP methods; IDP analysis; experimental characterization of IDPs; NMR Spectroscopy; NMR Spectroscopy and IDPs; Modeling of IDPs; IDP simulation; IDP binding; IDR binding; computational models of IDP; membraneless organelles; fibrillation of IDPs; IDPs and drug discovery