Circulating Tumor Cells in Breast Cancer Metastatic Disease

Preface.- Introduction - Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs.- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis.- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression.- Methodology for the Isolation and Analysis of CTCs.- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing.- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs.- Relevance of CTC Clusters in Breast Cancer Metastasis.- Epigenetics of Circulating Tumor Cells in Breast Cancer.- Circulating Tumor Cells: Applications for Early Breast Cancer.- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer.

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• Oncologia
• Biotecnologia
• Pesquisa médica
• Biologia do desenvolvimento

circulating tumor cells;breast cancer;epithelial to mesenchymal transition;dormancy;metastasis;prognostic biomarker;predictive biomarker