Acute Lymphoblastic Leukemia in Children and Adolescents

?Part I: Epidemiology and Predisposition of ALL. Genetic predisposition for leukemia.- Association of leukemia with genetic diseases. Part II: Biology and Diagnostics of ALL. Genetic aberrations and profiles in Bcp ALL.- Genetic aberrations and profiles in T ALL.- Features of ALL in children, adolescents, and young adults.- Immunological Diagnosis.- MRD response: FCM, Ig/Tcr PCR, NGS. Part III: Stratification and treatment considerations in ALL. Stratification and treatment of Bcp ALL and T-ALL.- Stratification and treatment of Adolescents/AYA.- CNS therapy .- Stratification and treatment of Down Syndrome .- Stratification and treatment of Infants.- Stratification and treatment of BCR/ABL and ABL class fusion. Part IV: Immunotherapy in ALL. Immunotherapy with monoclonal antibodies.- Immunotherapy with CAR-T. Part V: Strategies for patients with Lymphoblastic Lymphoma/mature B-ALL. Stratification and treatment of lymphoblastic lymphomas.- Stratification and treatment of mature B ALLs. Part VI: Strategies for patients with refractory or relapsed ALL. Relapses: classification and treatment.- HSCT in 1rst CR and after subsequent CRs: indications, conditioning regimens. Part VII: Toxicity and Late effects following ALL treatment. Genetic disposition for toxicity Late toxicity including SMN.- late effects after HSCT. Part VIII: Perspectives and Future directions.- Global disparities in ALL treatment and outcome.- New agents.

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• Faixas etárias: crianças
• Oncologia
• Grupos etários: adolescentes
• Hematologia
• Medicina pediátrica

B-Precursor ALL;T-ALL;Minimal residual disease;Genetic predisposition;Childhood ALL;Bcp ALL;Immunotherapy in ALL;Lymphoblastic Lymphoma;Mature B-ALL;Relapsed ALL;Late effects of ALL treatment