Acetaminophen Toxicity

Acetaminophen Toxicity

Experimental and Clinical Advances

Rumack, Barry; McGill, Mitchell; Jaeschke, Hartmut

Elsevier Science Publishing Co Inc

11/2024

400

Mole

Inglês

9780443158773

Pré-lançamento - envio 15 a 20 dias após a sua edição

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PART I: Foundational Aspects 1. History of Acetaminophen 2. Intracellular Signaling Mechanisms of Cell Death. 3. Hepatic MAP kinase signaling pathways in APAP-induced cell death 4. Adaptive Mechanisms modulating APAP-induced Cell Death 5. Mode of Cell Death 6. Inflammation 7. Hepatic Regeneration 8. Translation of Acetaminophen Hepatotoxicity Mechanisms from Models to Humans 9. Renal Toxicity 10. Genomics, Proteomics and Metabolomics Part II: Clinical and Therapeutic 11. Pharmacokinetics and pharmacodynamics - the absorption, distribution, metabolism and excretion of acetaminophen orally and intravenously 12. Minimally Invasive Clinical Biomarkers for use in Acetaminophen Hepatotoxicity 13. Adducts 14. The Rumack-Matthew Nomogram: Development, evolution, and use 15. Pathophysiology of Acetaminophen Overdose 16. Kings College Criteria and Liver Transplantation 17. Sustained-Release Acetaminophen 18. Acetaminophen, Ethanol and other Co-Ingestions 19. N-Acetylcysteine (NAC) 20. Fomepizole 21. Pre-Hospital, Poison Center and Initial Hospital Care of Overdose and Potential Overdosed Patients 22. Epidemiology NPDS (Poison Center Data) CDC and Other Databases 23. Acetaminophen safety in chronic liver diseases
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Acetaminophen; hepatotoxicity; toxicity; drug toxicity; drug safety; medical toxicology; clinical toxicology; Acetylcysteine; Fomepizole